Abstract
Three new aromatic butenolides, gymnoascolides A-C (1-3), have been isolated from the Australian soil ascomycete Gymnoascus reessii and assigned structures on the basis of detailed spectroscopic analysis. The absolute configurations of gymnoascolides B (2) and C (3) at C-5 were solved using a combination of chemical derivatization and quantum chemical simulations.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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4-Butyrolactone / analogs & derivatives*
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4-Butyrolactone / chemistry
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4-Butyrolactone / isolation & purification
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4-Butyrolactone / pharmacology
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Animals
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology
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Ascomycota / chemistry*
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Australia
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Bacillus subtilis / drug effects
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Haemonchus / drug effects
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Soil Microbiology
Substances
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Antifungal Agents
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gymnoascolide A
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gymnoascolide B
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gymnoascolide C
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4-Butyrolactone