Abstract
The in vitro activity of uperin 3.6, alone or combined with six antibiotics, against gram-positive cocci, including Rhodococcus equi, methicillin-resistant staphylococci, and vancomycin-resistant enterococci, was investigated. All isolates were inhibited at concentrations of 1 to 16 mg/liter. Synergy was demonstrated when uperin 3.6 was combined with clarithromycin and doxycycline.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amphibian Proteins / pharmacology*
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Anti-Bacterial Agents / pharmacology
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Clarithromycin / pharmacology
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Doxycycline / pharmacology
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Drug Synergism
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Enterococcus / drug effects
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Gram-Positive Cocci / drug effects*
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Immunocompromised Host*
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Methicillin Resistance
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Microbial Sensitivity Tests
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Peptides / pharmacology*
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Rhodococcus equi / drug effects
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Staphylococcus / drug effects
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Vancomycin Resistance
Substances
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Amphibian Proteins
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Anti-Bacterial Agents
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Peptides
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uperin 3.6 peptide, Uperoleia mjobergii
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Clarithromycin
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Doxycycline