Abstract
The effects of simvastatin treatment on Chlamydia pneumoniae lung infection, inflammation, and serum lipids in mouse model were studied. Simvastatin decreased viable chlamydial counts and increased inflammatory cell infiltrates in the lung tissue, suggesting that simvastatin treatment had both antichlamydial and immunomodulatory effects during an acute C. pneumoniae infection.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Chlamydia Infections / drug therapy*
-
Chlamydia Infections / microbiology
-
Chlamydophila pneumoniae*
-
Dietary Fats
-
Female
-
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
-
Lipids / blood
-
Lung Diseases / drug therapy*
-
Lung Diseases / microbiology
-
Mice
-
Simvastatin / therapeutic use*
Substances
-
Dietary Fats
-
Hydroxymethylglutaryl-CoA Reductase Inhibitors
-
Lipids
-
Simvastatin