Abstract
Fluoroquinolone resistance in tuberculosis may rapidly emerge. Mice infected with high titers of aerosolized Mycobacterium tuberculosis and treated for 8 weeks with four concentrations of moxifloxacin (0.125, 0.25, 0.50, and 1.0%) mixed into the diet had drug concentrations of 2.4, 4.1, 5.3, and 17.9 microg/ml, respectively, in blood. Selection of fluoroquinolone-resistant mutants occurred in all surviving mice.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Anti-Bacterial Agents / pharmacology*
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Aza Compounds / therapeutic use*
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Body Weight / drug effects
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DNA Gyrase / genetics
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DNA Primers
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Diet
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Drug Resistance, Bacterial
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Eating
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Female
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Fluoroquinolones / pharmacology*
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Mice
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Mice, Inbred BALB C
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Moxifloxacin
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Mycobacterium tuberculosis / drug effects*
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Quinolines / therapeutic use*
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Reverse Transcriptase Polymerase Chain Reaction
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Tuberculosis / drug therapy*
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Tuberculosis / microbiology*
Substances
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Anti-Bacterial Agents
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Aza Compounds
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DNA Primers
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Fluoroquinolones
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Quinolines
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DNA Gyrase
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Moxifloxacin