Abstract
The binding of the norepinephrine transporter radioligand, (S,S)-[18F]FMeNER-D2, to human brain post-mortem was examined in vitro by whole hemisphere autoradiography. The rank order for the density of labelling was: locus coeruleus>>cortex approximately cerebellum approximately thalamus>caudate approximately putamen. The NET-selectivity of binding was confirmed by co-incubation with desipramine. The dual NET/SERT inhibitor duloxetine also inhibited specific binding, whereas PE2I or citalopram had no evident effect.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Adrenergic Uptake Inhibitors / pharmacology
-
Autopsy
-
Autoradiography
-
Brain / metabolism*
-
Brain / pathology
-
Desipramine / pharmacology
-
Duloxetine Hydrochloride
-
Fluorine Radioisotopes / pharmacokinetics
-
Humans
-
Morpholines / pharmacokinetics*
-
Postmortem Changes
-
Radioligand Assay
-
Thiophenes / pharmacology
Substances
-
2-(alpha-(2-fluoromethoxyphenoxy)benzyl)morpholine
-
Adrenergic Uptake Inhibitors
-
Fluorine Radioisotopes
-
Morpholines
-
Thiophenes
-
Duloxetine Hydrochloride
-
Desipramine