Abstract
Ten phenylethanoid glycosides, forsythoside B, acteoside, 2'-acetylacteoside, poliumoside, brandioside, echinacoside, isoacteoside, cistanoside H and E-tubuloside E as well as a new compound, Z-tubuloside E, were isolated from the n-BuOH fraction of Callicarpa dichotoma Raeuschel (Verbenaceae) by bioactivity-guided fractionation using glutamate-injured primary cultures of rat cortical cells as a screening system. These phenylethanoid glycosides significantly attenuated glutamate-induced neurotoxicity at concentrations ranging from 0.1 to 10 microM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Callicarpa*
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Cerebral Cortex / cytology
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Cerebral Cortex / drug effects
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Dose-Response Relationship, Drug
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Female
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Glutamic Acid
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Glycosides / administration & dosage
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Glycosides / pharmacology
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Glycosides / therapeutic use
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In Vitro Techniques
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Neuroprotective Agents / administration & dosage
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Neuroprotective Agents / pharmacology*
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Neuroprotective Agents / therapeutic use
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Phytotherapy*
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Plant Leaves
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Plant Stems
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Rats
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Rats, Sprague-Dawley
Substances
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Glycosides
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Neuroprotective Agents
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Plant Extracts
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Glutamic Acid