Facile synthesis of highly functionalized N-methyl amino acid esters without side-chain protection

Org Lett. 2005 Sep 15;7(19):4111-2. doi: 10.1021/ol051441w.

Abstract

[reaction: see text] The facile, two-pot synthesis of N-methyl amino acid esters by way of reductive amination is presented. Side chain protection schemes are not required, the starting materials are all commercially available, and the synthetic method is straightforward and affords desired product in very high yield.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amino Acids / chemistry*
  • Esters / chemical synthesis
  • Esters / chemistry*
  • Methylation
  • Molecular Structure

Substances

  • Amino Acids
  • Esters