Abstract
Silica and asbestos exposure are thought to belong to the triggering factors of antineutrophil cytoplasm antibodies (ANCA)-associated vasculitis. We carried out a study to find out whether patients with pulmonary involvement attributable to ANCA-associated vasculitis (AAV) have been exposed to silicon-containing materials. Thirty-one patients (12 women, 19 men, median age 51 years) were interviewed using a structured questionnaire. Occupational exposure to silicon-containing chemicals was reported by 22.6% of the patients (12.9% to SiO2, 9.7% to asbestos), compared with 0% of control subjects (p<0.05). Our findings support the pathophysiologic role of silica in AAV.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Age Distribution
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Aged
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Antibodies, Antineutrophil Cytoplasmic / immunology
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Asbestos / adverse effects*
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Asbestosis / epidemiology*
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Asbestosis / etiology
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Czech Republic / epidemiology
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Environmental Monitoring
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Epidemiological Monitoring
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Female
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Humans
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Incidence
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Male
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Middle Aged
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Occupational Exposure / adverse effects*
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Retrospective Studies
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Risk Assessment
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Sex Distribution
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Silicon Dioxide / adverse effects*
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Silicosis / epidemiology*
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Silicosis / etiology
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Surveys and Questionnaires
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Vasculitis, Leukocytoclastic, Cutaneous / epidemiology
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Vasculitis, Leukocytoclastic, Cutaneous / etiology*
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Vasculitis, Leukocytoclastic, Cutaneous / immunology
Substances
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Antibodies, Antineutrophil Cytoplasmic
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Asbestos
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Silicon Dioxide