Abstract
The structure-based design and synthesis of a series of novel biphenyl sulfonamide carboxylic acids as potent MMP-13 inhibitors with selectivity over MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-14, Aggrecanase 1, and TACE are described.
MeSH terms
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Amination
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Benzofurans / chemistry
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Carboxylic Acids / chemical synthesis
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Carboxylic Acids / chemistry
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Carboxylic Acids / pharmacology
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Collagenases / metabolism
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Inhibitory Concentration 50
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Matrix Metalloproteinase 13
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Matrix Metalloproteinase Inhibitors*
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Molecular Structure
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Structure-Activity Relationship
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Sulfur / chemistry
Substances
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Benzofurans
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Carboxylic Acids
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Enzyme Inhibitors
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Matrix Metalloproteinase Inhibitors
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Sulfur
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Collagenases
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Matrix Metalloproteinase 13