Treatment-outcome for synchronous head-and-neck and oesophageal squamous cell carcinoma

Radiother Oncol. 2005 Dec;77(3):267-70. doi: 10.1016/j.radonc.2005.07.004. Epub 2005 Sep 9.

Abstract

Background and purpose: Although head & neck and oesophageal carcinomas occur synchronously in up to 12%, almost no data on feasibility and outcome after radiotherapy are available.

Materials and methods: From 1989 to 2002, 24 patients were treated at Tuebingen University and Fulda hospital with a radiation based, curative approach. These were analyzed retrospectively.

Results: The median overall survival was 37 (1-69) months with a few long-term survivors with a median follow-up of 26 months for patients at risk. 7 local recurrences occurred. No major toxicity was seen.

Discussion: Even though the prognosis of synchronous head & neck and oesophageal carcinomas is grim, long-term survival is possible. A radiation-based approach is feasible and can be chosen for a curative treatment approach which we recommend.

MeSH terms

  • Aged
  • Carcinoma, Squamous Cell / pathology
  • Carcinoma, Squamous Cell / radiotherapy*
  • Esophageal Neoplasms / pathology
  • Esophageal Neoplasms / radiotherapy*
  • Female
  • Head and Neck Neoplasms / pathology
  • Head and Neck Neoplasms / radiotherapy*
  • Humans
  • Male
  • Middle Aged
  • Neoplasms, Second Primary / pathology
  • Neoplasms, Second Primary / radiotherapy*
  • Prognosis
  • Retrospective Studies
  • Survival Analysis
  • Treatment Outcome