Abstract
To compare autonomic effects of botulinum toxin (BTX), we randomized patients with cervical dystonia to receive either BTX-A or BTX-B in a double-blind manner. Efficacy and physiologic questionnaire measures of autonomic function were assessed at baseline and 2 weeks after injection. Patients treated with BTX-B had less saliva production (p < 0.01) and greater severity of constipation (p = 0.037) than those treated with BTX-A, but did not differ in other tests of autonomic functions.
Publication types
-
Clinical Trial
-
Comparative Study
-
Randomized Controlled Trial
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adolescent
-
Adult
-
Aged
-
Autonomic Nervous System / drug effects*
-
Autonomic Nervous System / physiopathology
-
Autonomic Nervous System Diseases / chemically induced*
-
Autonomic Nervous System Diseases / physiopathology
-
Botulinum Toxins / administration & dosage
-
Botulinum Toxins / adverse effects*
-
Botulinum Toxins, Type A / administration & dosage
-
Botulinum Toxins, Type A / adverse effects*
-
Cardiovascular Physiological Phenomena / drug effects
-
Cholinergic Fibers / drug effects*
-
Cholinergic Fibers / physiology
-
Dose-Response Relationship, Drug
-
Double-Blind Method
-
Enteric Nervous System / drug effects
-
Enteric Nervous System / physiopathology
-
Female
-
Humans
-
Male
-
Middle Aged
-
Neuromuscular Agents / administration & dosage
-
Neuromuscular Agents / adverse effects
-
Presynaptic Terminals / drug effects
-
Presynaptic Terminals / physiology
-
Reflex, Pupillary / drug effects
-
Reflex, Pupillary / physiology
-
Respiratory Physiological Phenomena / drug effects
-
Salivation / drug effects
-
Torticollis / drug therapy*
Substances
-
Neuromuscular Agents
-
rimabotulinumtoxinB
-
Botulinum Toxins
-
Botulinum Toxins, Type A