Metachronous extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) and peripheral T-cell lymphoma unspecified: histologic, immunophenotypic, and molecular documentation

Onkologie. 2005 Aug;28(8-9):423-6. doi: 10.1159/000086528. Epub 2005 Aug 29.

Abstract

Background: Coexistence of B- and T-cell lymphoid malignancies has been reported sporadically.

Case report: A 68-year-old woman developed a lymphoid neoplasm in the large intestine and a second lymphoid neoplasm in the esophagus, 24 months after the diagnosis of the first lymphoma. Immunophenotypic analyses were consistent with extranodal marginal zone B-cell mucosa-associated lymphoid tissue type (MALT type) and peripheral T-cell unspecified lymphomas in the large intestine and the esophagus, respectively. The molecular analysis confirmed the B-clonal genotype of the first lymphoma, and disclosed a biclonal genotype of the second one (composite T- and B-cell lymphoma). No evidence of Epstein-Barr virus (EBV) association was shown in either tumor.

Conclusion: B- and T-cell neoplasms represent two distinct malignancies rather than progression of the same neoplastic clone.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antibodies, Viral / blood
  • B-Lymphocytes / immunology
  • B-Lymphocytes / pathology
  • Biomarkers, Tumor / genetics
  • Biopsy
  • Colonic Neoplasms / genetics
  • Colonic Neoplasms / immunology
  • Colonic Neoplasms / pathology*
  • Colonic Neoplasms / surgery
  • Epstein-Barr Virus Infections / genetics
  • Epstein-Barr Virus Infections / immunology
  • Epstein-Barr Virus Infections / pathology
  • Esophageal Neoplasms / genetics
  • Esophageal Neoplasms / immunology
  • Esophageal Neoplasms / pathology*
  • Esophagus / pathology
  • Female
  • Gene Rearrangement / genetics
  • Genes, T-Cell Receptor gamma
  • Herpesvirus 4, Human / immunology
  • Humans
  • Immunoglobulin M / blood
  • Immunophenotyping*
  • Intestinal Mucosa / pathology
  • Lymphoma, B-Cell, Marginal Zone / genetics
  • Lymphoma, B-Cell, Marginal Zone / immunology
  • Lymphoma, B-Cell, Marginal Zone / pathology*
  • Lymphoma, B-Cell, Marginal Zone / surgery
  • Lymphoma, T-Cell, Peripheral / genetics
  • Lymphoma, T-Cell, Peripheral / immunology
  • Lymphoma, T-Cell, Peripheral / pathology*
  • Mitotic Index
  • Neoplasm Invasiveness
  • Neoplasms, Second Primary / genetics
  • Neoplasms, Second Primary / immunology
  • Neoplasms, Second Primary / pathology*
  • Neoplasms, Second Primary / surgery
  • Polymerase Chain Reaction
  • T-Lymphocytes / immunology
  • T-Lymphocytes / pathology

Substances

  • Antibodies, Viral
  • Biomarkers, Tumor
  • Immunoglobulin M