Pisa syndrome without neuroleptic exposure in a patient with Parkinson's disease: case report

Mov Disord. 2006 Feb;21(2):270-3. doi: 10.1002/mds.20711.

Abstract

We report on a patient affected by Parkinson's disease who developed over a period of a few weeks a tonic deviation of her head, neck, and trunk fitting the typical description of Pisa syndrome (PS). This patient was under stable levodopa and pramipexole treatment and had never been exposed to any psychotropic or antiemetic drugs before or at the time she developed the postural abnormality. Because dopamine transporter imaging revealed bilateral and symmetrical reduction of striatal uptake, we suggest that PS is not primarily related to side differences in dopaminergic denervation or drug exposure.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antiparkinson Agents / administration & dosage*
  • Antiparkinson Agents / adverse effects
  • Antipsychotic Agents / administration & dosage*
  • Cerebral Cortex / physiopathology
  • Corpus Striatum / physiopathology
  • Dopamine Plasma Membrane Transport Proteins / physiology
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Dystonia Musculorum Deformans / diagnosis*
  • Dystonia Musculorum Deformans / physiopathology
  • Female
  • Humans
  • Levodopa / administration & dosage*
  • Levodopa / adverse effects
  • Parkinson Disease / diagnosis*
  • Parkinson Disease / drug therapy
  • Parkinson Disease / physiopathology
  • Syndrome
  • Tomography, Emission-Computed, Single-Photon

Substances

  • Antiparkinson Agents
  • Antipsychotic Agents
  • Dopamine Plasma Membrane Transport Proteins
  • Levodopa