The novel gluconeogenesis inhibitor FR225654 that originates from Phoma sp. no. 00144. I. Taxonomy, fermentation, isolation and physico-chemical properties

Yoshihiro Ohtsu; Hiromi Sasamura; Miho Tanaka; Yasuhisa Tsurumi; Seiji Yoshimura; Shigehiro Takase; Toshihiro Shibata; Motohiro Hino; Hidenori Nakajima

doi:10.1038/ja.2005.58

The novel gluconeogenesis inhibitor FR225654 that originates from Phoma sp. no. 00144. I. Taxonomy, fermentation, isolation and physico-chemical properties

J Antibiot (Tokyo). 2005 Jul;58(7):447-51. doi: 10.1038/ja.2005.58.

Authors

Yoshihiro Ohtsu¹, Hiromi Sasamura, Miho Tanaka, Yasuhisa Tsurumi, Seiji Yoshimura, Shigehiro Takase, Toshihiro Shibata, Motohiro Hino, Hidenori Nakajima

Affiliation

¹ Fermentation Research Laboratories, Fujisawa Pharmaceutical Co, Ltd. [email protected]

PMID: 16161482
DOI: 10.1038/ja.2005.58

Abstract

FR225654, a novel gluconeogenesis inhibitor, was isolated from the culture broth of Phoma sp. No. 00144 and purified by adsorptive resin and reverse-phase column chromatography. This compound is a potent inhibitor of gluconeogenesis and is a promising candidate of anti-diabetic agent.

MeSH terms

Animals
Cells, Cultured
Fermentation
Fungi*
Gluconeogenesis / drug effects*
Hepatocytes / drug effects*
Hepatocytes / metabolism
Hypoglycemic Agents / chemistry
Hypoglycemic Agents / isolation & purification*
Hypoglycemic Agents / pharmacology
Molecular Structure
Naphthalenes / chemistry
Naphthalenes / isolation & purification*
Naphthalenes / pharmacology
Rats

Substances

FR225654
Hypoglycemic Agents
Naphthalenes