Abstract
The first carbohydrate-free aminoglycoside analogs bearing the 2-deoxystreptamine moiety were synthesized from asymmetrically protected 2-deoxystrepamine and subsequently demonstrated to have significant binding to the 16S A-site rRNA target and moderate functional activity.
MeSH terms
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Aminoglycosides / chemical synthesis*
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Aminoglycosides / chemistry
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Aminoglycosides / pharmacology*
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Inhibitory Concentration 50
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Molecular Structure
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Protein Biosynthesis / drug effects
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RNA, Ribosomal, 16S / genetics
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RNA, Ribosomal, 16S / metabolism*
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Transcription, Genetic / drug effects
Substances
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Aminoglycosides
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RNA, Ribosomal, 16S