Abstract
Several new prenylnaphthohydroquinone derivatives have been prepared through the Diels-Alder condensation between alpha-myrcene and 1,2-benzoquinone and evaluated for their cytotoxic activity against A-549, HT-29 and MB-231 cultured cell lines. All of them have shown GI50 values in the microM level.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / toxicity*
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Cell Line, Tumor
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Cell Survival / drug effects
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Humans
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Inhibitory Concentration 50
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Isomerism
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Molecular Structure
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Naphthoquinones / chemical synthesis
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Naphthoquinones / chemistry*
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Naphthoquinones / toxicity*
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Prenylamine / analogs & derivatives*
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Prenylamine / chemical synthesis
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Prenylamine / chemistry
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Prenylamine / toxicity
Substances
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Antineoplastic Agents
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Naphthoquinones
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prenyl-1,2-naphthohydroquinone
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Prenylamine