Rationale for the potential use of calcitonin in osteoarthritis

D H Manicourt; J P Devogelaer; M Azria; S Silverman

Rationale for the potential use of calcitonin in osteoarthritis

J Musculoskelet Neuronal Interact. 2005 Jul-Sep;5(3):285-93.

Authors

D H Manicourt¹, J P Devogelaer, M Azria, S Silverman

Affiliation

¹ Department of Rheumatology, University Hospital St Luc, Universite Catholique de Louvain, Brussels, Belgium.

PMID: 16172519

Abstract

This review provides evidence that osteoarthritis (OA) or a major subset of OA is not only a disease of cartilage but also a disorder of subchondral bone. This review also discusses the potential efficacy of a bone and cartilage active agent, calcitonin, and discusses how calcitonin might be useful in the pharmaceutical treatment of OA.

Publication types

Review

MeSH terms

Bone Density Conservation Agents / pharmacology*
Bone Density Conservation Agents / therapeutic use
Bone Remodeling / drug effects
Bone Remodeling / physiology
Bone and Bones / drug effects*
Bone and Bones / physiopathology
Calcitonin / pharmacology*
Calcitonin / therapeutic use
Cartilage, Articular / drug effects*
Cartilage, Articular / physiopathology
Humans
Joints / metabolism
Joints / physiology
Joints / physiopathology
Osteoarthritis / drug therapy*
Osteoarthritis / physiopathology
Stress, Mechanical
Weight-Bearing / physiology

Substances

Bone Density Conservation Agents
Calcitonin