The use of patient-oriented outcomes, in particular health-related quality if life (HRQOL), to evaluate coronary revascularization is continuously increasing. Current data underline that patients undergoing conventional CABG show a tremendous improvement of HRQOL status as early as 3 months postoperatively. There seems to be no clear benefit concerning HRQOL for off-pump coronary surgery versus conventional CABG. The benefits of minimal invasive CABG via mini-thoracotomy are compromised by increased incidence of pain during the immediate postoperative period. Totally endoscopic approaches seem to be more effective with regard to pain reduction and resume of every day activities. Compared to catheter-based interventions there is evidence that conventional CABG offers significant advantages over PCI. The influence of drug-eluting stents and newer surgical techniques on HRQOL remains to be determined. Inclusion of HRQOL data in CABG and PCI databases can play a central role in order to identify patient groups who benefit the most from each revascularization strategy.