Linkage disequilibrium mapping of quantitative-trait Loci by selective genotyping

Am J Hum Genet. 2005 Oct;77(4):661-9. doi: 10.1086/491658. Epub 2005 Aug 15.

Abstract

The principles of linkage disequilibrium mapping of dichotomous diseases can be well applied to the mapping of quantitative-trait loci through the method of selective genotyping. In 1999, M. Slatkin considered a truncation selection (TS) approach. We propose in this report an extended TS approach and an extreme-rank-selection (ERS) approach. The properties of these selection approaches are studied analytically. By using a simulation study, we demonstrate that both the extended TS approach and the ERS approach provide remarkable improvements over Slatkin's original TS approach.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Genotype
  • Humans
  • Linkage Disequilibrium*
  • Quantitative Trait Loci*