Abstract
Pathophysiological changes associated with anthrax lethal toxin included loss of plasma proteins, decreased platelet count, slower clotting times, fibrin deposits in tissue sections, and gross and histopathological evidence of hemorrhage. These findings suggest that blood vessel leakage and hemorrhage lead to disseminating intravascular coagulation and/or circulatory shock as an underlying pathophysiological mechanism.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Anthrax / blood*
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Anthrax / etiology
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Anthrax / pathology*
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Antigens, Bacterial / toxicity*
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Bacterial Toxins / toxicity*
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Blood Vessels / physiopathology
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Bronchi / pathology
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Disseminated Intravascular Coagulation / microbiology*
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Disseminated Intravascular Coagulation / physiopathology
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Fibrinogen / analysis
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Hemorrhage / microbiology*
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Hemorrhage / pathology
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Hemorrhage / physiopathology
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Mice
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Myocardium / chemistry
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Myocardium / pathology
Substances
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Antigens, Bacterial
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Bacterial Toxins
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anthrax toxin
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Fibrinogen