Abstract
Neutrophils are important in controlling early infections with the intracellular bacterium Rhodococcus equi. Antineutrophil monoclonal antibody (RB6-8C5)-induced neutrophil deficiency during the first week after experimental infection of mice with R. equi resulted in more severe disease and significantly increased tissue concentrations of R. equi.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Actinomycetales Infections / immunology*
-
Actinomycetales Infections / microbiology
-
Animals
-
Antibodies, Monoclonal / pharmacology
-
Female
-
Liver / microbiology
-
Lung / microbiology
-
Mice
-
Mice, Inbred BALB C
-
Neutrophils / drug effects
-
Neutrophils / immunology*
-
Rhodococcus equi* / isolation & purification
-
Spleen / microbiology