Abstract
Zyzzyanones B, C, and D (2-4), three new dipyrroloquinones with a pyrrolo[3,2-f]indole-4,8(1H,7H)-dione skeleton, have been isolated from the Australian marine sponge Zyzzya fuliginosa. The known zyzzyanone A, makaluvamines C, E, G, H, and L, damirones A and B, 3,7-dimethylguanine, and 4-hydroxybenzoic acid were also isolated. The structures of the new compounds 2-4 were established by extensive NMR spectroscopic data. Compounds 2-4 showed moderate cytotoxic activity against mouse Ehrlich carcinoma cells (IC50 25 microg/mL).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Australia
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Drug Screening Assays, Antitumor
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Mice
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Porifera / chemistry*
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Pyrroles / chemistry
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Pyrroles / isolation & purification*
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Pyrroles / pharmacology
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Quinones / chemistry
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Quinones / isolation & purification*
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Quinones / pharmacology
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Pyrroles
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Quinones
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zyzzyanone B
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zyzzyanone C
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zyzzyanone D