Overweight and obesity in deltaF508 homozygous cystic fibrosis

Dagmar Kastner-Cole; Colin N A Palmer; Simon A Ogston; Anil Mehta; Somnath Mukhopadhyay

doi:10.1016/j.jpeds.2005.06.003

Overweight and obesity in deltaF508 homozygous cystic fibrosis

J Pediatr. 2005 Sep;147(3):402-4. doi: 10.1016/j.jpeds.2005.06.003.

Authors

Dagmar Kastner-Cole¹, Colin N A Palmer, Simon A Ogston, Anil Mehta, Somnath Mukhopadhyay

Affiliation

¹ Division of Maternal and Child Health Sciences, Institute of Cardiovascular Research and Biomedical Research Centre, Ninewells Hospital, Dundee, Scotland, United Kingdom.

PMID: 16182686
DOI: 10.1016/j.jpeds.2005.06.003

Abstract

Overweight (9%) and obesity (1%) in patients with cystic fibrosis homozygous for the deltaF508 mutation (CFdeltaF508) were non-trivial. Children with CFdeltaF508, in contrast to the general population, showed a positive association between body mass index and lung function for all body mass index z-scores.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Body Mass Index
Child
Child, Preschool
Cystic Fibrosis / complications*
Cystic Fibrosis / genetics
Cystic Fibrosis / physiopathology*
Cystic Fibrosis Transmembrane Conductance Regulator / genetics*
Female
Forced Expiratory Volume
Homozygote
Humans
Infant
Lung / physiopathology*
Male
Middle Aged
Nutritional Status
Obesity / complications*
Obesity / physiopathology*

Substances

CFTR protein, human
cystic fibrosis transmembrane conductance regulator delta F508
Cystic Fibrosis Transmembrane Conductance Regulator