Y-SNP-genotyping - a new approach in forensic analysis

Forensic Sci Int. 2005 Nov 25;154(2-3):128-36. doi: 10.1016/j.forsciint.2004.09.129. Epub 2004 Nov 23.

Abstract

Y-chromosomal DNA polymorphisms, especially Y-STRs are well established in forensic routine case work. The STRs are used for identification in paternity deficiency cases and stain analysis with complicate mixtures of male and female DNA. In contrast, Y-chromosomal SNPs are a new tool in forensic investigations. At present, Y-SNPs are mainly used in molecular anthropology for evolutionary studies. Nevertheless, these markers could also provide very useful information for the analysis of forensic cases. The aim of the presented study was to test Y-SNP-typing for stain analyses using different methods-SNaPshot and MALDI-TOF MS. Both methods are based on the principle of minisequencing. The selected Y-SNP markers are suited to define the most important European haplogroups.

MeSH terms

  • Chromosomes, Human, Y*
  • DNA / analysis
  • DNA Fingerprinting / methods*
  • DNA Primers
  • Genetic Markers
  • Genotype
  • Haplotypes
  • Humans
  • Male
  • Polymerase Chain Reaction
  • Polymorphism, Single Nucleotide*
  • White People

Substances

  • DNA Primers
  • Genetic Markers
  • DNA