Abstract
The synthesis of two caffeoyl-coumarin conjugates, derived from sagecoumarin, has been accomplished, starting from ferulic acid, isoferulic acid and sesamol. Both compounds exhibited potent inhibitory activities at micromolar concentrations against HIV-1 integrase in 3'-end processing reaction but were less effective against HIV-1 replication in a single-round infection assay of HeLa-beta-gal-CD4+ cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Caffeic Acids / chemical synthesis*
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Caffeic Acids / chemistry
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Caffeic Acids / isolation & purification
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Caffeic Acids / pharmacology*
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Coumarins / chemistry
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Dimerization
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HIV Integrase / metabolism*
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HIV Integrase Inhibitors / chemical synthesis*
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HIV Integrase Inhibitors / chemistry
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HIV Integrase Inhibitors / isolation & purification
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HIV Integrase Inhibitors / pharmacology*
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Inhibitory Concentration 50
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Molecular Structure
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Salvia officinalis / chemistry*
Substances
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Caffeic Acids
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Coumarins
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HIV Integrase Inhibitors
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coumarin
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HIV Integrase