It is shown that low volumes of plasmapheresis can be used in combined treatment of patients with autoimmune hemolytic anemia who did not respond well to the routine therapy. It is a safe detoxication method with immunocorrective, hyposensitizing action that promotes more effective transfusion of red blood cell pack and washed red blood cells, and permits a significant decrease in glucocorticosteroid doses. It has been suggested that plasmapheresis could be used at early stages of the disease treatment.