Abstract
The in vitro activities of DA-7867, a novel oxazolidinone, and garenoxacin (BMS-284756) were compared to those of linezolid in 67 susceptible and drug-resistant clinical isolates of Mycobacterium tuberculosis. DA-7867 was the most active drug with an MIC(90) of 0.125 microg/ml, compared to the MIC(90)s of 4 microg/ml of garenoxacin and 2 microg/ml of linezolid.
MeSH terms
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Acetamides / pharmacology
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Antitubercular Agents / pharmacology*
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Dose-Response Relationship, Drug
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Drug Resistance, Bacterial / drug effects*
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Fluoroquinolones / pharmacology*
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Linezolid
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Microbial Sensitivity Tests
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Mycobacterium tuberculosis / drug effects*
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Mycobacterium tuberculosis / isolation & purification
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Oxazolidinones / pharmacology*
Substances
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Acetamides
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Antitubercular Agents
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DA-7867
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Fluoroquinolones
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Oxazolidinones
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Linezolid
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garenoxacin