Abstract
The dhps sequences of 55 Plasmodium vivax isolates (39 from Thailand and 16 from elsewhere) revealed mutant Pvdhps at codons 383 and/or 553 (A --> G) in 33 isolates, all from Thailand. Mutations of Pvdhps and Pvdhfr were correlated. Multiple mutations were associated with high-grade sulfadoxine-pyrimethamine resistance.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antimalarials / pharmacology
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Antimalarials / therapeutic use
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Codon
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DNA, Protozoan / genetics
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DNA, Protozoan / isolation & purification
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Dihydropteroate Synthase / chemistry
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Dihydropteroate Synthase / genetics*
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Drug Combinations
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Drug Resistance
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Genes, Protozoan*
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Haplotypes
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Malaria, Vivax / drug therapy
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Malaria, Vivax / enzymology
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Malaria, Vivax / genetics*
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Nucleic Acid Amplification Techniques
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Plasmodium vivax / drug effects
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Plasmodium vivax / enzymology*
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Plasmodium vivax / genetics*
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Plasmodium vivax / isolation & purification
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Point Mutation
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Polymerase Chain Reaction
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Polymorphism, Genetic*
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Prevalence
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Protein Structure, Tertiary
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Pyrimethamine / pharmacology
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Pyrimethamine / therapeutic use
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Sulfadoxine / pharmacology
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Sulfadoxine / therapeutic use
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Thailand / epidemiology
Substances
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Antimalarials
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Codon
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DNA, Protozoan
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Drug Combinations
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Sulfadoxine
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Dihydropteroate Synthase
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Pyrimethamine