Three-component, room temperature crotylation catalyzed by solid-supported Brønsted acid: enantioselective synthesis of homoallylic carbamates

Org Lett. 2005 Oct 13;7(21):4701-4. doi: 10.1021/ol051885s.

Abstract

[reaction: see text] A heterogeneous, three-component crotylation of in situ generated N-acyl iminium ions has been developed. This reaction proceeds under ambient temperature in MeCN and is catalyzed by macroporous polystyrene-bound sulfonic acid (MP-TsOH). Workup is accomplished by filtration, upon which the catalyst is recoverable. A range of homoallylic amine equivalents have been prepared from the corresponding aldehydes, carbamates, and chiral (E)-crotylsilanes in a highly stereoselective manner.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carbamates / chemical synthesis*
  • Carbamates / chemistry
  • Catalysis
  • Molecular Structure
  • Polystyrenes / chemistry*
  • Porosity
  • Silanes / chemistry*
  • Stereoisomerism
  • Sulfonic Acids / chemistry*
  • Temperature

Substances

  • Carbamates
  • Polystyrenes
  • Silanes
  • Sulfonic Acids
  • crotylsilane