Pharmacological correction of hemostasis-regulating function of the lungs in rats with uncomplicated pregnancy and experimental gestosis

Bull Exp Biol Med. 2005 Jun;139(6):651-4. doi: 10.1007/s10517-005-0368-1.

Abstract

Fetal growth retardation, hypercoagulation, and changes in pulmonary fibrinolytic activity were observed during experimental gestosis induced by long-term feeding of a high-sodium diet. The course of fraxiparine treatment to correct gestosis improved hemostasis-regulating lung function, decreased coagulation activity of the arterial blood, and increased the weights of the placenta and fetus.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Anticoagulants / pharmacology*
  • Birth Weight / drug effects
  • Blood Coagulation
  • Blood Coagulation Disorders / therapy
  • Female
  • Fetal Growth Retardation / etiology
  • Fetus / drug effects
  • Fibrinogen / analysis
  • Fibrinogen / drug effects
  • Hemostasis / drug effects*
  • Lung / physiopathology*
  • Nadroparin / pharmacology*
  • Placenta / drug effects
  • Pre-Eclampsia / blood*
  • Pre-Eclampsia / etiology
  • Pre-Eclampsia / therapy
  • Pregnancy
  • Random Allocation
  • Rats

Substances

  • Anticoagulants
  • Nadroparin
  • Fibrinogen