Lymphocyte interactions with endothelial cells

Y Shimizu; W Newman; Y Tanaka; S Shaw

doi:10.1016/0167-5699(92)90151-V

Lymphocyte interactions with endothelial cells

Immunol Today. 1992 Mar;13(3):106-12. doi: 10.1016/0167-5699(92)90151-V.

Authors

Y Shimizu¹, W Newman, Y Tanaka, S Shaw

Affiliation

¹ Dept of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor 48109.

PMID: 1622542
DOI: 10.1016/0167-5699(92)90151-V

Abstract

Adhesion of lymphocytes to endothelium is vital to lymphocyte migration into lymphoid tissue and into inflammatory sites. In this review, Yoji Shimizu and colleagues identify the molecules that mediate lymphocyte-endothelial cell adhesion, describe the underlying principles of lymphocyte migration, and discuss a model of the sequence of events that allow a lymphocyte to successfully attach to endothelium and migrate into the surrounding tissue.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Cell Adhesion Molecules / physiology*
Cell Movement / physiology
Endothelium, Vascular / cytology*
Humans
T-Lymphocytes / physiology*

Substances

Cell Adhesion Molecules

Grants and funding

AI31126/AI/NIAID NIH HHS/United States