Resolution of EBV(+) CNS lymphoma with appearance of CSF EBV-specific T cells

Ann Neurol. 2005 Nov;58(5):788-92. doi: 10.1002/ana.20640.

Abstract

Current knowledge of Epstein-Barr virus (EBV)-specific T-cell responses in the cerebrospinal fluid (CSF) of patients with EBV-related lymphoproliferative disease (EBV-LPD) in the central nervous system (CNS) is very limited. Here, we present two recipients of hematopoietic stem cell transplants with EBV-LPD in the CNS. EBV-specific CD8(+) T lymphocytes were detected in CSF and peripheral blood using major histocompatibility complex (MHC) class I multimers loaded with EBV-derived peptides. The appearance of EBV-specific CD8(+) T cells in CSF and blood correlated with neurological improvement and disappearance of EBV-LPD. These observations suggest a role for EBV-specific CD8(+) T cells in the control of EBV-LPD in the CNS.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • CD8 Antigens / metabolism
  • Central Nervous System Neoplasms / cerebrospinal fluid
  • Central Nervous System Neoplasms / surgery
  • Central Nervous System Neoplasms / virology*
  • Epstein-Barr Virus Infections / cerebrospinal fluid
  • Epstein-Barr Virus Infections / etiology*
  • Epstein-Barr Virus Infections / virology
  • Female
  • Flow Cytometry / methods
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Hematopoietic Stem Cell Transplantation / methods
  • Herpesvirus 4, Human / isolation & purification*
  • Humans
  • Lymphoma / cerebrospinal fluid
  • Lymphoma / surgery
  • Lymphoma / virology*
  • Male
  • Middle Aged
  • Nuclear Proteins / metabolism
  • T-Lymphocytes / cytology
  • T-Lymphocytes / immunology
  • T-Lymphocytes / virology*
  • Time Factors
  • Trans-Activators / metabolism

Substances

  • CD8 Antigens
  • MHC class II transactivator protein
  • Nuclear Proteins
  • Trans-Activators