[Lack of direct cytotoxic effect of intracellular nanotubes]

G Ital Med Lav Ergon. 2005 Jul-Sep;27(3):383-4.
[Article in Italian]

Abstract

Nanotubes have a great therapeutic potential due to their astounding physico-chemical features, the possibility to be funtionalised for ad hoc uses, and the specific interaction of nanotubes as such with life molecules (DNA and proteins). These features recommend a thorough toxicological study before widespread pharmaceutic use. We provide evidence that culture cells with phagocytic potential internalise multi wall nanotubes (10-50 nm average size). This is not accompanied by cytotoxicity in terms of induction of &apoptosis or necrosis at the doses used (up to 125 microg/mI).

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apoptosis*
  • Cells, Cultured
  • Culture Media
  • Humans
  • Nanotubes, Carbon / toxicity*
  • Necrosis
  • Phagocytes
  • Time Factors
  • Toxicity Tests

Substances

  • Culture Media
  • Nanotubes, Carbon