Giant congenital nevus and chronic progressive ascending hemiparesis (Mills syndrome). Report of a case

Ital J Neurol Sci. 1992 Apr;13(3):259-63. doi: 10.1007/BF02224400.

Abstract

We describe the case of a 20 year old boy with a giant congenital nevus who developed a chronic progressive ascending hemiparesis. The association of the pigmented lesion with a focal neurological deficit is pathognomonic for neurocutaneous melanosis complicated by a leptomeningeal melanoma. MR imaging at 1.5 tesla ruled out such a possibility and showed a small aspecific pontine lesion along the route of the corticospinal tract. We discuss possible etiologies.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Hemiplegia / etiology*
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Melanosis / diagnosis
  • Nevus, Pigmented / complications
  • Nevus, Pigmented / congenital*
  • Nevus, Pigmented / pathology
  • Skin Neoplasms / complications
  • Skin Neoplasms / congenital*
  • Skin Neoplasms / pathology
  • Syndrome