First case report of X linked dystonia parkinsonism (XDP) or 'lubag' in Australia

J Clin Neurosci. 2005 Nov;12(8):945-6. doi: 10.1016/j.jocn.2004.10.012. Epub 2005 Oct 20.

Abstract

Purpose: To present the first genetically supported case of X linked dystonia parkinsonism (XDP) or 'lubag' reported in an Australian hospital.

Methods: We performed PCR amplification of microsatellite markers in and around the previously described segregating region for the XDP haplotype.

Results: Linkage was confirmed using markers ZNF261, DXS10017, and DXS10018.

Conclusion: We present the first case of XDP or 'lubag' reported in an Australian hospital. It highlights the enlarging role of genetic testing in facilitating the diagnosis of dystonia in a clinical environment where a disease like XDP is rare, and where a corroborating family history may be unavailable.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Australia
  • Dystonic Disorders / genetics*
  • Dystonic Disorders / physiopathology
  • Genetic Diseases, X-Linked / genetics*
  • Genetic Diseases, X-Linked / physiopathology
  • Genetic Linkage
  • Genetic Markers
  • Haplotypes
  • Humans
  • Male
  • Microsatellite Repeats / genetics
  • Parkinsonian Disorders / genetics*
  • Parkinsonian Disorders / physiopathology
  • Polymerase Chain Reaction

Substances

  • Genetic Markers