Synthesis and biological evaluation of NAD analogs as human pyridine nucleotide adenylyltransferase inhibitors

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):477-9. doi: 10.1081/ncn-200060013.

Abstract

NAD analogs modified at the ribose adenylyl moiety, named N-2'-MeAD and Na-2'-MeAD, were synthesized as ligands of pyridine nucleotide (NMN/NaMN) adenylyltransferase (NMNAT). Both dinucleotides resulted selective inhibitors against human NMNAT-3 isoenzyme.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / pharmacology
  • Chemistry, Pharmaceutical / methods
  • Drug Design
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / pharmacology
  • Humans
  • Ligands
  • Models, Chemical
  • NAD / analogs & derivatives
  • NAD / chemical synthesis*
  • Nicotinamide-Nucleotide Adenylyltransferase / antagonists & inhibitors*

Substances

  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Ligands
  • NAD
  • Nicotinamide-Nucleotide Adenylyltransferase