Abstract
Novel thioiso pyrimidine and purine nucleosides substituted with exocyclic methylene have been synthesized, starting from D-xylose. Cyclization of the dimesylate to the 4-thiosugar 6a proceeded in pure SN2 reaction in the presence of allylic functional group.
MeSH terms
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / pharmacology
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Chemistry, Pharmaceutical / methods
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Drug Design
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Hydrocarbons / chemistry
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Methane / analogs & derivatives*
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Methane / chemistry
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Models, Chemical
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Nucleosides / chemical synthesis*
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Nucleosides / chemistry
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Stereoisomerism
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Temperature
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Xylose / chemistry
Substances
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Antiviral Agents
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Hydrocarbons
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Nucleosides
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carbene
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Xylose
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Methane