Synthesis, spectroscopic, cytotoxic, and DNA binding studies of binuclear 2,2'-bipyridine-platinum(II) and -palladium(II) complexes of meso-alpha,alpha'-diaminoadipic and meso-alpha,alpha'-diaminosuberic acids

J Inorg Biochem. 1992 Feb 1;45(2):135-48. doi: 10.1016/0162-0134(92)80008-j.

Abstract

Four new binuclear complexes of formula [M2(bipy)2(BAA)]Cl2 (where M is Pt(II) or Pd(II), bipy is 2,2'-bipyridine, and BAA is a dianion of meso-alpha-alpha'-diaminoadipic acid (DAA) or meso-alpha,alpha'-diaminosuberic acid (DSA) have been synthesized. These complexes have been characterized by chemical analysis and ultraviolet-visible, infrared, and 1H NMR spectroscopy. The mode of binding of ligands in these complexes has been ascertained by infrared and detailed 1H NMR spectroscopy. These complexes are 1:2 electrolyte in conductivity water. They have also been tested against P388 lymphocytic leukemia cells and their target is DNA molecules. [Pt2(bipy)2(DSA)]Cl2, [Pd2(bipy)2(DSA)Cl2, and [Pd2(bipy)2(DAA)]Cl2 show I.D.50 values comparable or lower than cis-diamminedichloroplatinum(II) and [Pt(bipy)(Ala)]Cl. In addition, binding studies of [Pt2(bipy)2(DSA)]Cl2 and [Pd2(bipy)2(DAA)]Cl2 to calf thymus DNA have been carried out and the mode of binding seems to be hydrogen bonding, as suggested earlier for analogous mononuclear amino acid-DNA complexes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipates / chemistry*
  • Adipates / metabolism
  • Adipates / pharmacology
  • Amino Acids, Diamino / chemistry*
  • Amino Acids, Diamino / metabolism
  • Amino Acids, Diamino / pharmacology
  • Animals
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / metabolism
  • Antineoplastic Agents / pharmacology
  • Cattle
  • DNA / metabolism*
  • Leukemia P388 / drug therapy
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Organometallic Compounds / chemistry*
  • Organometallic Compounds / metabolism
  • Organometallic Compounds / pharmacology
  • Organoplatinum Compounds / chemistry*
  • Organoplatinum Compounds / metabolism
  • Organoplatinum Compounds / pharmacology
  • Spectrum Analysis

Substances

  • Adipates
  • Amino Acids, Diamino
  • Antineoplastic Agents
  • Organometallic Compounds
  • Organoplatinum Compounds
  • 2,2'-bipyridine-alpha,alpha'-diaminoadipic acid platinum(II)
  • 2,2'-bipyridine-alpha, alpha'-diaminoadipic acid palladium(II)
  • 2,2'-bipyridine-alpha,alpha'-diaminosuberic acid platinum(II)
  • 2,2'-bipyridine-alpha, alpha-diaminosuberic acid palladium(II)
  • DNA