The amyloid-beta precursor protein: integrating structure with biological function

Constanze Reinhard; Sébastien S Hébert; Bart De Strooper

doi:10.1038/sj.emboj.7600860

The amyloid-beta precursor protein: integrating structure with biological function

EMBO J. 2005 Dec 7;24(23):3996-4006. doi: 10.1038/sj.emboj.7600860. Epub 2005 Oct 27.

Authors

Constanze Reinhard¹, Sébastien S Hébert, Bart De Strooper

Affiliation

¹ Laboratory for Neuronal Cell Biology and Gene Transfer, Department of Human Genetics, Center for Human Genetics, KU Leuven and VIB, Leuven, Belgium.

Abstract

Proteolytic processing of the amyloid-beta precursor protein (APP) generates the Abeta amyloid peptide of Alzheimer's disease. The biological function of APP itself remains, however, unclear. In the current review, we study in detail the different subdomains of APP and try to assign functional significance to particular structures identified in the protein.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Amyloid beta-Protein Precursor / chemistry*
Amyloid beta-Protein Precursor / physiology*
Animals
Humans
Protein Structure, Tertiary / physiology
Structure-Activity Relationship

Substances

Amyloid beta-Protein Precursor