A new chemical tool for exploring the role of the PDE4D isozyme in leukocyte function

Robert J Chambers; Kristin Abrams; Tessa A Castleberry; John B Cheng; Douglas A Fisher; Ajith V Kamath; Anthony Marfat; David O Nettleton; Joann D Pillar; Eben D Salter; Alissa L Sheils; John T Shirley; Claudia R Turner; John P Umland; Kelvin T Lam

doi:10.1016/j.bmcl.2005.10.026

A new chemical tool for exploring the role of the PDE4D isozyme in leukocyte function

Bioorg Med Chem Lett. 2006 Feb;16(3):718-21. doi: 10.1016/j.bmcl.2005.10.026. Epub 2005 Nov 2.

Authors

Robert J Chambers¹, Kristin Abrams, Tessa A Castleberry, John B Cheng, Douglas A Fisher, Ajith V Kamath, Anthony Marfat, David O Nettleton, Joann D Pillar, Eben D Salter, Alissa L Sheils, John T Shirley, Claudia R Turner, John P Umland, Kelvin T Lam

Affiliation

¹ Groton Laboratories, Pfizer, Inc., Eastern Point Road, Groton, CT 06340, USA. [email protected]

PMID: 16263279
DOI: 10.1016/j.bmcl.2005.10.026

Abstract

Nicotinamide (2) is a potent and selective inhibitor of the PDE4D isozyme and as a chemical tool selectively blocks eosinophil mediator release and chemotaxis thus linking the role of PDE4D to eosinophil function.

Publication types

Comparative Study

MeSH terms

3',5'-Cyclic-AMP Phosphodiesterases / antagonists & inhibitors
3',5'-Cyclic-AMP Phosphodiesterases / physiology*
Chemotaxis / drug effects
Cyclic Nucleotide Phosphodiesterases, Type 4
Eosinophils / drug effects
Eosinophils / physiology*
Isoenzymes / antagonists & inhibitors
Isoenzymes / chemistry
Isoenzymes / metabolism
Leukocytes / drug effects
Leukocytes / physiology*
Niacinamide / antagonists & inhibitors*
Phosphodiesterase Inhibitors / chemistry
Phosphodiesterase Inhibitors / pharmacology*
Rolipram / chemistry
Rolipram / pharmacology

Substances

Isoenzymes
Phosphodiesterase Inhibitors
Niacinamide
3',5'-Cyclic-AMP Phosphodiesterases
Cyclic Nucleotide Phosphodiesterases, Type 4
Rolipram