Effective combination therapy using interferon-gamma and interleukin-2 for disseminated Mycobacterium avium complex infection in a pediatric patient with AIDS

Yukio Sekiguchi; Kozo Yasui; Takashi Yamazaki; Kazunaga Agematsu; Norimoto Kobayashi; Kenichi Koike

doi:10.1086/498026

Effective combination therapy using interferon-gamma and interleukin-2 for disseminated Mycobacterium avium complex infection in a pediatric patient with AIDS

Clin Infect Dis. 2005 Dec 1;41(11):e104-6. doi: 10.1086/498026. Epub 2005 Oct 21.

Authors

Yukio Sekiguchi¹, Kozo Yasui, Takashi Yamazaki, Kazunaga Agematsu, Norimoto Kobayashi, Kenichi Koike

Affiliation

¹ Department of Emergency and Critical Care Medicine, Shinshu University School of Medicine, Matsumoto, Japan.

PMID: 16267723
DOI: 10.1086/498026

Abstract

A 5-year-old girl presented with disseminated Mycobacterium avium complex infection during advanced human immunodeficiency virus infection. Interferon-gamma or interleukin-2 monotherapy showed only limited effects. Use of a combination of interferon-gamma and interferon-2 resulted in a remarkable improvement in the patient's condition, accompanied by an increase in circulating CD4+ T cells.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Acquired Immunodeficiency Syndrome / complications*
CD4 Lymphocyte Count
Child, Preschool
Drug Therapy, Combination
Humans
Interferon-gamma / therapeutic use*
Interleukin-2 / therapeutic use*
Male
Mycobacterium avium-intracellulare Infection / complications*
Mycobacterium avium-intracellulare Infection / drug therapy*

Substances

Interleukin-2
Interferon-gamma