Abstract
Streptococcus mutans UA159, the genome sequence reference strain, exhibits nonlantibiotic mutacin activity. In this study, bioinformatic and mutational analyses were employed to demonstrate that the antimicrobial repertoire of strain UA159 includes mutacin IV (specified by the nlm locus) and a newly identified bacteriocin, mutacin V (encoded by SMU.1914c).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Proteins / genetics*
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Bacterial Proteins / metabolism
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Bacteriocins / biosynthesis*
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Computational Biology
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Genome, Bacterial*
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Microbial Sensitivity Tests
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Mutagenesis
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Reference Standards
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Streptococcus mitis / drug effects
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Streptococcus mutans / classification
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Streptococcus mutans / genetics*
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Streptococcus mutans / metabolism
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Streptococcus oralis / drug effects
Substances
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Bacterial Proteins
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Bacteriocins
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mutacin IV