Abstract
Structure-activity relationship (SAR) studies of the novel 2-[3-di and trifluoromethyl-5-alkylamino pyrazo-1-yl]-5-methanesulfonyl (SO(2)Me)/sulfamoyl (SO(2)NH(2))-pyridine derivatives for canine COX enzymes are described. The studies led to the identification of 2e as lead with potent in vitro activity, selectivity, and in vivo activity in dogs and cats.
MeSH terms
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Administration, Oral
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Animals
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Cats
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Cyclooxygenase 2 / drug effects*
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Cyclooxygenase 2 Inhibitors* / chemical synthesis
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Cyclooxygenase 2 Inhibitors* / chemistry
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Cyclooxygenase 2 Inhibitors* / pharmacokinetics
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Disease Models, Animal
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Dogs
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Drug Evaluation, Preclinical
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In Vitro Techniques
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Molecular Structure
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Pyrazoles* / chemical synthesis
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Pyrazoles* / chemistry
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Pyrazoles* / pharmacokinetics
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Structure-Activity Relationship
Substances
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3-difluoromethyl-5-(cis-2,6-dimethylmorpholin-4-yl)-1-(5-methanesulfonyl-pyridin-2-yl)-1H-pyrazole-4-carbonitrile
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Cyclooxygenase 2 Inhibitors
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Pyrazoles
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Cyclooxygenase 2