Abstract
The authors investigated whether the cognitive impairments associated with white matter hyperintensities (WMH) in normal elderly subjects are exacerbated by any anticholinergic medications being taken by the subjects. Results showed serum anticholinergic activity (SAA) and WMH volume to have a synergistic interaction such that the cognitive decrements associated with increasing WMH volume were greatest in those older individuals in the highest quartile of the SAA distribution.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acetylcholine / metabolism
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Aged
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Aged, 80 and over
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Aging / metabolism
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Aging / pathology
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Brain / blood supply
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Brain / metabolism
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Brain / pathology
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Cerebral Infarction / complications
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Cerebral Infarction / metabolism
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Cerebral Infarction / physiopathology*
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Cerebrovascular Disorders / complications
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Cerebrovascular Disorders / metabolism
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Cerebrovascular Disorders / physiopathology*
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Cognition / drug effects
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Cognition / physiology
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Cognition Disorders / chemically induced*
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Cognition Disorders / physiopathology
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Cognition Disorders / psychology*
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Disease Progression
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Female
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Humans
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Male
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Muscarinic Antagonists / adverse effects*
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Muscarinic Antagonists / blood
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Nerve Fibers, Myelinated / metabolism
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Nerve Fibers, Myelinated / pathology
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Neuropsychological Tests
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Psychomotor Performance / drug effects
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Psychomotor Performance / physiology
Substances
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Muscarinic Antagonists
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Acetylcholine