Abstract
Infection in chicken flocks on a farm, where AI outbreak took place in 1998, was monitored in a four-year consecutive period and 22 H9N2 subtype viruses were isolated. The HA gene and antigenicity of 9 strains among isolates were compared with that of isolate of 1998. The results indicated that mutations of HA genes of H9 subtype influenza A viruses were observed during five years. However these mutations of HA genes didn't lead to sufficient antigenic variation to change the cross-protective pattern of these strains. These findings may be fruitful for making further study of genetic mutations of AIVs in the field and improving the control strategies.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Chickens
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China / epidemiology
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Disease Outbreaks / veterinary
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Hemagglutination
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Hemagglutinin Glycoproteins, Influenza Virus / genetics*
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Hemagglutinin Glycoproteins, Influenza Virus / immunology
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Influenza A Virus, H9N2 Subtype / classification
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Influenza A Virus, H9N2 Subtype / genetics*
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Influenza A Virus, H9N2 Subtype / immunology
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Influenza A Virus, H9N2 Subtype / isolation & purification
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Influenza in Birds / epidemiology
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Influenza in Birds / immunology
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Influenza in Birds / virology*
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Mutation*
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Phylogeny
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Poultry Diseases / immunology
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Poultry Diseases / virology*
Substances
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Hemagglutinin Glycoproteins, Influenza Virus