Abstract
Blood flow contrast between tumor and normal tissues in patients with malignant and benign breast cancer was measured by diffuse optical correlation methods. The measurements were carried out with a hand-held optical probe that was manually scanned over the tumor-bearing breast. Increased blood flow was observed in tumor regions relative to healthy tissue, and control subjects did not exhibit significant blood flow heterogeneity. The measurements introduce a new optical contrast for diffuse optical mammography.
Publication types
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Controlled Clinical Trial
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Blood Flow Velocity*
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Breast Neoplasms / blood supply*
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Breast Neoplasms / pathology*
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Equipment Design
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Equipment Failure Analysis
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Humans
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Image Interpretation, Computer-Assisted / methods*
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Neovascularization, Pathologic / pathology*
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Spectrophotometry, Infrared / instrumentation*
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Spectrophotometry, Infrared / methods
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Tomography, Optical / instrumentation*
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Tomography, Optical / methods