In order to study the epidemiology of tuberculosis (TB) in Zabol, situated in the Southeast of Iran, this study was performed. Two thousand seven hundred and twenty-nine cases of tuberculosis disease were identified during 1998-2002. The notification rate was 135/100,000 population in 2002, which was higher than this rate in previous years. The notification rate of TB in Afghan population was significantly higher than Iranian population (202 cases/100,000 in Afghan and 122 cases/100,000 in Iranian population. The case notifications in 1998-2001 were 134, 131, 130, and 130 in 100,000 populations, respectively. The prevalence of smear-positive cases was 76/100,000 population in 2002 and the ratio of smear-positive cases to smear-negative and extrapulmonary cases was 1.46. This region remains high TB rates. It is necessary to pay attention to the detection of TB, by making their register in order to enhance the effectiveness and to reduce the cost of existing methods.