Early treatment failure in severe malaria resulting from abnormally low plasma quinine concentrations

Paul N Newton; Steven Ward; Brian J Angus; Wirongrong Chierakul; Arjen Dondorp; Ronnatrai Ruangveerayuth; Kamolrat Silamut; Pramote Teerapong; Yupin Suputtamongkol; Sornchai Looareesuwan; Nicholas J White

doi:10.1016/j.trstmh.2005.01.008

Early treatment failure in severe malaria resulting from abnormally low plasma quinine concentrations

Trans R Soc Trop Med Hyg. 2006 Feb;100(2):184-6. doi: 10.1016/j.trstmh.2005.01.008. Epub 2005 Nov 10.

Authors

Paul N Newton¹, Steven Ward, Brian J Angus, Wirongrong Chierakul, Arjen Dondorp, Ronnatrai Ruangveerayuth, Kamolrat Silamut, Pramote Teerapong, Yupin Suputtamongkol, Sornchai Looareesuwan, Nicholas J White

Affiliation

¹ Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand. [email protected]

PMID: 16289166
DOI: 10.1016/j.trstmh.2005.01.008

Abstract

A patient admitted with severe Plasmodium falciparum malaria in western Thailand had an early treatment failure with quinine, despite full dosing. Plasma quinine concentrations were subtherapeutic. Abnormal quinine pharmacokinetics may explain sporadic reports of quinine treatment failures in severe malaria.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Antimalarials / blood
Antimalarials / pharmacokinetics
Antimalarials / therapeutic use*
Humans
Malaria, Falciparum / drug therapy*
Male
Quinine / blood
Quinine / pharmacokinetics
Quinine / therapeutic use*
Thailand
Treatment Failure

Substances

Antimalarials
Quinine

Grants and funding

Wellcome Trust/United Kingdom