Clostridium perfringens enterotoxin damages the human intestine in vitro

M E Fernández Miyakawa; V Pistone Creydt; F A Uzal; B A McClane; C Ibarra

doi:10.1128/IAI.73.12.8407-8410.2005

Clostridium perfringens enterotoxin damages the human intestine in vitro

Infect Immun. 2005 Dec;73(12):8407-10. doi: 10.1128/IAI.73.12.8407-8410.2005.

Authors

M E Fernández Miyakawa¹, V Pistone Creydt, F A Uzal, B A McClane, C Ibarra

Affiliation

¹ California Animal Health and Food Safety Laboratory-San Bernardino Branch, University of California-Davis, 105 W. Central Avenue, San Bernardino, CA 92408. [email protected].

Abstract

In vitro, Clostridium perfringens enterotoxin (CPE) binds to human ileal epithelium and induces morphological damage concurrently with reduced short-circuit current, transepithelial resistance, and net water absorption. CPE also binds to the human colon in vitro but causes only slight morphological and transport changes that are not statistically significant.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Colon / drug effects*
Colon / pathology
Enterotoxins / toxicity*
Humans
Ileum / drug effects*
Ileum / pathology
In Vitro Techniques
Intestinal Mucosa / drug effects
Intestinal Mucosa / pathology*

Substances

Enterotoxins
enterotoxin, Clostridium

Abstract

Publication types

MeSH terms

Substances

Grants and funding