Response to vinorelbine and low-dose cyclophosphamide chemotherapy in two patients with desmoplastic small round cell tumor

Pediatr Blood Cancer. 2007 Nov;49(6):864-6. doi: 10.1002/pbc.20682.

Abstract

We report two cases of abdominal desmoplastic small round cell tumor (DSRCT) that showed a clinical response to the vinorelbine/low-dose cyclophosphamide combination that has been claimed to be effective for rhabdomyosarcoma. This observation may prompt further investigation into the activity of such a regimen in DSRCT patients with recurrent or refractory disease, with a view to a possible future role as maintenance therapy in controlling minimal residual disease in patients who achieve complete remission with intensive induction multimodality therapy.

Publication types

  • Case Reports

MeSH terms

  • Abdominal Neoplasms / diagnostic imaging
  • Abdominal Neoplasms / drug therapy*
  • Abdominal Neoplasms / pathology
  • Adolescent
  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
  • Biopsy, Fine-Needle
  • Cyclophosphamide / administration & dosage
  • Humans
  • Liver Neoplasms / diagnostic imaging
  • Liver Neoplasms / drug therapy*
  • Liver Neoplasms / pathology
  • Male
  • Neoplasm Metastasis
  • Neoplasm, Residual
  • Radiography
  • Remission Induction
  • Rhabdomyosarcoma / drug therapy
  • Sarcoma, Small Cell / diagnostic imaging
  • Sarcoma, Small Cell / drug therapy*
  • Sarcoma, Small Cell / pathology
  • Vinblastine / administration & dosage
  • Vinblastine / analogs & derivatives*
  • Vinorelbine

Substances

  • Vinblastine
  • Cyclophosphamide
  • Vinorelbine